{"product_id":"c14orf169-polyclonal-antibody-e-ab-17743","title":"C14orf169 Polyclonal Antibody - E-AB-17743","description":"\u003cp\u003eC14orf169 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-17743-60, E-AB-17743-120, E-AB-17743-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: C14orf169\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 60S ribosomal protein L8 histidine hydroxylase; C14orf169; Chromosome 14 open reading frame 169 ; Histone lysine demethylase NO66; hsNO66; Hypothetical protein FLJ21802; Lysine-specific demethylase NO66; MAPJD; MYC associated protein with JmjC domain; NO66; NO66; Nucleolar protein 66; Ribosomal oxygenase NO66; ROX; Up regulated in lung cancer 2; URLC2\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9H6W3\u003c\/p\u003e\n\n\u003cp\u003eBackground: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7\/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7\/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.8 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human C14orf169\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:30-1:150, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43130655637683,"sku":"E-AB-17743-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43130655670451,"sku":"E-AB-17743-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43130655703219,"sku":"E-AB-17743-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8536dbdb-089b-4ae5-96f3-0ddfc75e32ed.png?v=1709810862","url":"https:\/\/afsbio.com\/products\/c14orf169-polyclonal-antibody-e-ab-17743","provider":"AFSBio Inc.","version":"1.0","type":"link"}