{"product_id":"c8orf4-polyclonal-antibody-e-ab-62494","title":"C8orf4 Polyclonal Antibody - E-AB-62494","description":"\u003cp\u003eC8orf4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62494-60, E-AB-62494-120, E-AB-62494-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: C8orf4\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: C8orf4; TC-1; TC1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction, Stem cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9NR00\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt\/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1\/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human C8orf4 (NP_064515.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43136870482099,"sku":"E-AB-62494-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43136870514867,"sku":"E-AB-62494-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43136870547635,"sku":"E-AB-62494-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_14c19f35-6be6-4ba8-ac8c-2b1b0e7b72db.png?v=1709993057","url":"https:\/\/afsbio.com\/products\/c8orf4-polyclonal-antibody-e-ab-62494","provider":"AFSBio Inc.","version":"1.0","type":"link"}