{"product_id":"cad-phospho-ser1859-rabbit-polyclonal-antibody-ra22630","title":"CAD (phospho-Ser1859) Rabbit Polyclonal Antibody - RA22630","description":"\u003cp\u003eCAD (phospho-Ser1859) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA22630-50, RA22630-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) Homo sapiens The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: WB 1:1000-2000\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5) ; Aspartate carbamoyltransferase (EC 2.1.3.2) ; Dihydroorotase (EC 3.5.2.3) ]\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 790\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 250\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P27708\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121131970739,"sku":"RA22630-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121132003507,"sku":"RA22630-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_311e7fb0-37f1-4a3f-9ebe-5b56d6166292.png?v=1773371434","url":"https:\/\/afsbio.com\/products\/cad-phospho-ser1859-rabbit-polyclonal-antibody-ra22630","provider":"AFSBio Inc.","version":"1.0","type":"link"}