{"product_id":"caldesmon-s783-polyclonal-antibody-bs1437","title":"Caldesmon (S783) Polyclonal Antibody-BS1437","description":"\u003cp\u003eCaldesmon (S783) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1437-50, BS1437-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q05682\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e \n\n\u003cp\u003eBackground: Caldesmon, Filamin 1, Nebulin and Villin are differentially expressed and regulated Actin binding proteins. Both muscular and non-muscular forms of Caldesmon have been identified and each has been shown to bind to Actin as well as to calmodulin and Myosin. Alternative splicing of the gene encoding Caldesmon results in five isoforms. Muscular Caldesmon (isoform 1), also designated high molecular weight Caldesmon or H-Caldesmon (H-CAD), is expressed predominantly on thin filaments in smooth muscle. Non-muscular Caldesmon (isoforms 2-5), also designated low molecular weight Caldesmon or L-Caldesmon (L-CAD), is widely expressed in non-muscle tissues and cells.\u003c\/p\u003e \n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Caldesmon (S783) polyclonal antibody detects endogenous levels of Caldesmon protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of Caldesmon (S783) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: MCF-7 whole cell lysate (20ug)\u003cbr\u003e\nLane 2: Hela whole cell lysate (40ug)\u003cbr\u003e\nLane 3: A549 whole cell lysate (40ug)\u003cbr\u003e\nLane 4: PC12 whole cell lysate (40ug)\u003cbr\u003e\nLane 5: MEF whole cell lysate (40ug), Immunohistochemistry (IHC) analyzes of Caldesmon (S783) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: 70-80 kDa non-muscle\u003cbr\u003e\n120-150 kDa smooth muscle\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Caldesmon; CDM; CALD1; CAD; CDM\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 750-800 of Human Caldesmon.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42953210757299,"sku":"BS1437-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42953210790067,"sku":"BS1437-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d5627abc-8883-4b62-a346-54caff905ba0.jpg?v=1705056835","url":"https:\/\/afsbio.com\/products\/caldesmon-s783-polyclonal-antibody-bs1437","provider":"AFSBio Inc.","version":"1.0","type":"link"}