Protein S100
Calgranulin
Migration inhibitory factor-related protein (MRP)
Source: Human Neutrophils
Catalogue Number: ATC04-10
Product Information
Extracellular release of calprotectin during cell damage/stress can be used as a marker for intestinal inflammation. There is growing evidence that faecal calprotectin correlates with mucosal disease activity which can be utilised as a monitoring response to relapse and treatments in inflammatory bowel disease. Measuring the concentration of calprotectin in faeces is an indirect measure of neutrophil infiltrate in the bowel mucosa.
AROTEC Diagnostics' Calprotectin is seen as a ~48kDa heterotetramer based on the size-exclusion profile observed.
Calprotectin datasheetClinical Indications
Inflammatory bowel disease (IBD)
MSDS
References
Kerkhoff C, Klempt M, Sorg C. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim. Biophys.Acta 1998, 1448:200-211
Gebhardt C, Nemeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol. 2006, 72:1622-1631
Korndörfer IP, Brueckner F, Skerra A. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins. J. Mol. Biol.2007, 370:887-898
Sherwood RA. Faecal markers of gastrointestinal inflammation. J. Clin. Pathol. 2012, 64:981-985
Smith LA, Gaya DR. Utility of calprotectin analysis in adult inflammatory bowel disease. World J. Gastroenterol. 2012, 18:6782-6789
Burri, E and Beglinger C. Faecal calprotection - a useful tool in the management of inflammatory bowel disease. Swiss Med. Wkly.2012, 142:w13557
Lewis JD. The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011, 140:1817-1826