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CALXCHOL Reagent

CALXCHOL Reagent

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CALIXAR’s CALXCHOL reagent is a non-ionic Calixarene based detergent / surfactant with three carboxylic groups and a cholesterol group.

5,11,17-tris[(carboxy)methyl]-25-monomethoxytriazolo-(3α-cholesteryl)-26,27,28-trihydroxycalix[4]arene

Compound name: CALXCHOL

Catalogue number: CALXCHOL_10MG, CALXCHOL_50MG, CALXCHOL_100MG

Molec. Formula: C64H74N3Na3O10

CAS: nd

MW: 1114.2 g/mol

pKa: na​

Percent Composition: C, 68.99; H, 9.69; N, 3.77; Na, 6.19; O, 14.36

Physical state: Beige powder

Purity (HPLC, 214nm): 85%

Retention time (RP18 HPLC)b: tR = 22.9 min

CMC: na

Exact mass​: nd

Stability: Store in <-20°C freezer for up to one year

Solubility Structure: Soluble in water (up to 4%)

 


CALIXAR utilizes a unique & a custom-built strategy 

CALIXAR’s CALXCHOL is a very gentle detergent used to stabilize native membrane proteins. CALXCHOL is non-ionic and therefore is not sensitive to ionic strength or pH changes is well adapted to stabilize many different specific membrane proteins.

CALXCHOL can help generate lipid detergent mixed micelles and protein detergent micelles. CALXCHOL also enables the stabilization of native and functional membrane proteins within a solution. CALXCHOL can also be employed as a protein chaperone to insert membrane proteins into liposomes.

CALXCHOL is provided in powder form and is used in an aqueous solution or buffer and can also be mixed within biological materials (biological membranes).

 

CALIXar’s CALXCHOL is non-ionic and therefore is not sensitive to ionic concentration or pH fluctuations and is able to stabilize precise membrane proteins. Due to the fluorinated chain, CALXCHOL does not solubilize lipid membranes.

CALIXAR’s CALXCHOL is a high-quality detergent / reagent used for research and medicine discovery projects. CALIXAR's structural studies are adapted for use in pharmaceutical, biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science domains.

 

  • Antibodies (including nanobodies, scaffold proteins, aptamers)
  • Small molecules
  • 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
  • Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
  • Antibody discovery (Immunization and display technologies)
  • Clinical stage (drug validation on reliable native DDLAC)

 

References

PROPRIETARY PATENT

Method for the synthesis of steroidic calixarene compounds and their use for extraction, solubilization and/or stabilization of native and functional membrane proteins.