CALIXAR’s CALXCHOL reagent is a non-ionic Calixarene based detergent / surfactant with three carboxylic groups and a cholesterol group.
Compound name: CALXCHOL
Catalogue number: CALXCHOL_10MG, CALXCHOL_50MG, CALXCHOL_100MG
Molec. Formula: C64H74N3Na3O10
MW: 1114.2 g/mol
Percent Composition: C, 68.99; H, 9.69; N, 3.77; Na, 6.19; O, 14.36
Physical state: Beige powder
Purity (HPLC, 214nm): 85%
Retention time (RP18 HPLC)b: tR = 22.9 min
Exact mass: nd
Stability: Store in <-20°C freezer for up to one year
Solubility Structure: Soluble in water (up to 4%)
CALIXAR utilizes a unique & a custom-built strategy
CALIXAR’s CALXCHOL is a very gentle detergent used to stabilize native membrane proteins. CALXCHOL is non-ionic and therefore is not sensitive to ionic strength or pH changes is well adapted to stabilize many different specific membrane proteins.
CALXCHOL can help generate lipid detergent mixed micelles and protein detergent micelles. CALXCHOL also enables the stabilization of native and functional membrane proteins within a solution. CALXCHOL can also be employed as a protein chaperone to insert membrane proteins into liposomes.
CALXCHOL is provided in powder form and is used in an aqueous solution or buffer and can also be mixed within biological materials (biological membranes).
Native Full-Length Proteins
CALIXar’s CALXCHOL is non-ionic and therefore is not sensitive to ionic concentration or pH fluctuations and is able to stabilize precise membrane proteins. Due to the fluorinated chain, CALXCHOL does not solubilize lipid membranes.
Specifically Made for Biotech
CALIXAR’s CALXCHOL is a high-quality detergent / reagent used for research and medicine discovery projects. CALIXAR's structural studies are adapted for use in pharmaceutical, biotechnology companies, as well as for academic teams (biochemists, structural biologists, pharmacologists, virologists) that are involved in the life science domains.
For Any Life Science Project
- Antibodies (including nanobodies, scaffold proteins, aptamers)
- Small molecules
- 3D Structures (cryoEM, XRay crystallography, NMR, SANS, SAXS)
- Drug discovery (Screening: HTS, FBDD, SBDD; Hit and lead validation)
- Antibody discovery (Immunization and display technologies)
- Clinical stage (drug validation on reliable native DDLAC)
Method for the synthesis of steroidic calixarene compounds and their use for extraction, solubilization and/or stabilization of native and functional membrane proteins.