{"product_id":"camkiiα-δ-phospho-t286-polyclonal-antibody-bs4773","title":"CaMKIIα\/δ (phospho-T286) Polyclonal Antibody - BS4773","description":"\u003cp\u003eCaMKIIα\/δ (phospho-T286) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4773-50, BS4773-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The Ca2+\/calmodμlin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine\/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine\/threonine protein kinase that is activated by Ca2+ and calmodμlin (CaM) and has been implicated in regμlation of the cell cycle and transcription. There are four CaMKII isozymes, designated α, β, γ and δ, which may or may not be co-expressed in the same tissue type. CaMKIIα is autophosphorylated on Thr 286 upon the binding of the Ca2+\/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+\/CaM trapping, which is thought to be involved in the synaptic encoding of information.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Calcium\/calmodμlin-dependent protein kinase type II subunit alpha, CaM kinase II subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968, CaMK2-a, CaMK2a, CaMK-2a, Calcium\/calmodμlin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, CAMK2D, CAMKD, CaMK2-δ, CaMK2δ, CaMK-2δ,\u003c\/p\u003e \n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human CaMKIIα around the phosphorylation site of Threonine 286.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-CaMKIIα\/δ (T286) polyclonal antibody detects endogenous levels of CaMKIIα\/δprotein only when phosphorylated at Thr286.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 54 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Phospholipase Signaling, Regμlation of Microtubμle Dynamics, G Protein-coupled Receptors Signaling to MAPK Erk, ErbB HER Signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: Q9UQM7\/Q13557\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946314358963,"sku":"BS4773-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946314391731,"sku":"BS4773-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/camkii%ce%b1-%ce%b4-phospho-t286-polyclonal-antibody-bs4773","provider":"AFSBio Inc.","version":"1.0","type":"link"}