{"product_id":"camkk2-phospho-ser511-rabbit-polyclonal-antibody-bt-ap06822","title":"CaMKK2 (Phospho-Ser511) Rabbit Polyclonal Antibody - BT-AP06822","description":"\u003cp\u003eCaMKK2 (Phospho-Ser511) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP06822-20, BT-AP06822-50, BT-AP06822-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene belongs to the Serine\/Threonine protein kinase family| and to the Ca(2+)\/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium\/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory| neuronal differentiation and migration| neurite outgrowth| and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Cancer; Signal transduction\u003c\/p\u003e \n\n\u003cp\u003eTarget Protein: CAMKK2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CaMKK2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q96RR4; Mouse: Q8C078; Rat: O88831\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CaMKK2;Ser511; Calcium\/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; EC 2.7.11.17; Calcium\/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 10645; Mouse: 207565; Rat: 83506\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45238974152883,"sku":"BT-AP06822-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45238974185651,"sku":"BT-AP06822-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238974218419,"sku":"BT-AP06822-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_403566ba-4848-41d4-93ba-69d227a75217.png?v=1769387420","url":"https:\/\/afsbio.com\/products\/camkk2-phospho-ser511-rabbit-polyclonal-antibody-bt-ap06822","provider":"AFSBio Inc.","version":"1.0","type":"link"}