{"product_id":"camkk2-polyclonal-antibody-ra22686","title":"CaMKK2 Polyclonal Antibody - RA22686","description":"\u003cp\u003eCaMKK2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA22686-50, RA22686-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: calcium\/calmodulin dependent protein kinase kinase 2 (CAMKK2) Homo sapiens The product of this gene belongs to the Serine\/Threonine protein kinase family, and to the Ca (2+) \/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium\/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK) . This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: CAMKK2; CAMKKB; KIAA0787; Calcium\/calmodulin-dependent protein kinase kinase 2; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; Calcium\/calmodulin-dependent protein kinase kinase beta; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC-p; IF (paraffin section) ; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 10645\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 65\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96RR4\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121139245235,"sku":"RA22686-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121139278003,"sku":"RA22686-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_00fa1e2c-038c-43f8-9d81-ab1fff83206d.png?v=1773371487","url":"https:\/\/afsbio.com\/products\/camkk2-polyclonal-antibody-ra22686","provider":"AFSBio Inc.","version":"1.0","type":"link"}