{"product_id":"camlg-polyclonal-antibody-e-ab-64807","title":"CAMLG Polyclonal Antibody - E-AB-64807","description":"\u003cp\u003eCAMLG Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-64807-60, E-AB-64807-120, E-AB-64807-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CAMLG\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CAMLG; CAML; GET2\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P49069\u003c\/p\u003e\n\n\u003cp\u003eBackground: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human CAMLG (NP_001736.1).\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:100   IF \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 38kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43148653756595,"sku":"E-AB-64807-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43148653789363,"sku":"E-AB-64807-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43148653822131,"sku":"E-AB-64807-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d5b1d59e-c382-4127-9613-e33298a40000.png?v=1710327387","url":"https:\/\/afsbio.com\/products\/camlg-polyclonal-antibody-e-ab-64807","provider":"AFSBio Inc.","version":"1.0","type":"link"}