{"product_id":"card11-m12-polyclonal-antibody-bs2228","title":"CARD11 (M12) Polyclonal Antibody-BS2228","description":"\u003cp\u003eCARD11 (M12) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS2228-50, BS2228-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9BXL7\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CARD11 polyclonal antibody detects endogenous levels of CARD11 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 133 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western Blot (WB) analysis of Carma 1 (M12) pAb at 1:500 dilution\u003cbr\u003e\n Lane1:K562 whole cell lysate(40ug)\u003cbr\u003e\n Lane2:The Thymus tissue lysate of Rat(30ug)\u003cbr\u003e\n Lane3:Myla2059 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Caspase recruitment domain-containing protein 11; CARD-containing MAGUK protein 1; Carma 1; CARD11; CARMA1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant full length Human CARD11.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42923481890995,"sku":"BS2228-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42923481923763,"sku":"BS2228-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_2f31599a-339e-44d4-98fa-87817269c2ad.jpg?v=1703850291","url":"https:\/\/afsbio.com\/products\/card11-m12-polyclonal-antibody-bs2228","provider":"AFSBio Inc.","version":"1.0","type":"link"}