{"product_id":"card11-polyclonal-antibody-e-ab-61552","title":"CARD11 Polyclonal Antibody - E-AB-61552","description":"\u003cp\u003eCARD11 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-61552-60, E-AB-61552-120, E-AB-61552-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CARD11\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CARD11; BENTA; BIMP3; CARMA1; IMD11; PPBL\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology,Epigenetics and Nuclear Signaling,Immunology,Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9BXL7\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human CARD11\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IF 1:50-1:100\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 133kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 133kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146169942195,"sku":"E-AB-61552-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146169974963,"sku":"E-AB-61552-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146170007731,"sku":"E-AB-61552-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_b21a925e-1149-4fb9-af41-14f8df3e092d.png?v=1710291566","url":"https:\/\/afsbio.com\/products\/card11-polyclonal-antibody-e-ab-61552","provider":"AFSBio Inc.","version":"1.0","type":"link"}