{"product_id":"card16-polyclonal-antibody-e-ab-17810","title":"CARD16 Polyclonal Antibody - E-AB-17810","description":"\u003cp\u003eCARD16 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-17810-60, E-AB-17810-120, E-AB-17810-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CARD16\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CAR16; CARD only domain-containing protein 1; CARD only protein ; CARD16; Caspase recruitment domain family; member 16; Caspase recruitment domain-containing protein 16; Caspase-1 dominant-negative inhibitor pseudo-ICE ; Caspase-1 inhibitor COP; COP; COP1; Pseudo interleukin 1 beta converting enzyme; Pseudo interleukin-1 beta converting enzyme; Pseudo interleukin-1beta converting enzyme ; PSEUDO-ICE\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q5EG05\u003c\/p\u003e\n\n\u003cp\u003eBackground: Caspase inhibitor. Acts as a regulator of procaspase-1\/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1.1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide of human CARD16\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Antigen affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43143866187955,"sku":"E-AB-17810-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43143866220723,"sku":"E-AB-17810-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43143866253491,"sku":"E-AB-17810-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_4afbcfaa-27a8-44a2-970d-3fe52764410b.png?v=1710242723","url":"https:\/\/afsbio.com\/products\/card16-polyclonal-antibody-e-ab-17810","provider":"AFSBio Inc.","version":"1.0","type":"link"}