{"product_id":"cardiac-troponin-i-tnni3-rabbit-pab-a0152","title":"Cardiac Troponin I (TNNI3) Rabbit pAb - A0152","description":"\u003cp\u003eCardiac Troponin I (TNNI3) Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A0152-20, A0152-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate\/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP, IF-P, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 24kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 28kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment)\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 7137\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P19429\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Cardiac Troponin I (TNNI3)\u003c\/p\u003e \n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 IP, 0.5μg-4μg antibody for 400μg-600μg extracts of whole cells IF-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction, Cell Biology Developmental Biology, Cytoskeleton, Microfilaments, Stem Cells, Cardiovascular, Angiogenesis, Heart, Contractility.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: TNNI3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189432606899,"sku":"A0152-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189432639667,"sku":"A0152-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a82d87f4-ac98-4744-b8a6-3022fc36763d.png?v=1766427094","url":"https:\/\/afsbio.com\/products\/cardiac-troponin-i-tnni3-rabbit-pab-a0152","provider":"AFSBio Inc.","version":"1.0","type":"link"}