{"product_id":"carkl-polyclonal-antibody-bt-ap01173","title":"CARKL Polyclonal Antibody - BT-AP01173","description":"\u003cp\u003eCARKL Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01173-20, BT-AP01173-50, BT-AP01173-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The sedoheptulokinase encoded by SHPK has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: SHPK\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CARKL Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 51504\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9UHJ6; Mouse: Q9D5J6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: SHPK; CARKL; Sedoheptulokinase; SHK; Carbohydrate kinase-like protein\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 23729; Mouse: 74637\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240156389555,"sku":"BT-AP01173-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240156422323,"sku":"BT-AP01173-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240156455091,"sku":"BT-AP01173-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_ff74324d-2aae-4daf-89ca-e8dd48999e53.png?v=1769404311","url":"https:\/\/afsbio.com\/products\/carkl-polyclonal-antibody-bt-ap01173","provider":"AFSBio Inc.","version":"1.0","type":"link"}