{"product_id":"cas-polyclonal-antibody-bt-ap01176","title":"CAS Polyclonal Antibody - BT-AP01176","description":"\u003cp\u003eCAS Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01176-20, BT-AP01176-50, BT-AP01176-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha\/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein (chromosome segregation 1 like) may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for CSE1L.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CSE1L\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IP, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CAS Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 110417\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P55060; Mouse: Q9ERK4\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1434\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240156586163,"sku":"BT-AP01176-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240156618931,"sku":"BT-AP01176-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240156651699,"sku":"BT-AP01176-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_e51efeeb-7104-4071-9dd1-915957bb2ff5.png?v=1769404313","url":"https:\/\/afsbio.com\/products\/cas-polyclonal-antibody-bt-ap01176","provider":"AFSBio Inc.","version":"1.0","type":"link"}