{"product_id":"casein-kinase-iα-phospho-tyr294-rabbit-polyclonal-antibody-es4857","title":"Casein Kinase Iα (phospho Tyr294) Rabbit Polyclonal Antibody - ES4857","description":"\u003cp\u003eCasein Kinase Iα (phospho Tyr294) Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4857-50, ES4857-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: CSNK1A1 (Casein Kinase 1 Alpha 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Infectious disease. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CSNK1G2. asein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at Ser-45. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed: 11955436, PubMed: 1409656, PubMed: 18305108). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed: 23902688). asein kinase I (CK1) is a monomeric serine-threonine protein kinase with 7 isoforms: alpha, beta, gamma1, gamma2, gamma3, delta and epsilon. CK1 is involved in many cellular processes including DNA repair, cell division, nuclear localization and membrane transport. Isoforms are also integral to development.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CSNK1A1, Casein kinase I isoform alpha, CKI-alpha, CK1, CSNK1A1L, Casein kinase I isoform alpha-like, CKI-alpha-like, CK1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CK-1 alpha around the phosphorylation site of Tyr294. AA range:260-309\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Casein Kinase Iα\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Phospho-Casein Kinase Iα (Y294) Polyclonal Antibody detects endogenous levels of Casein Kinase Iα protein only when phosphorylated at Y294.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Brain, Epithelium, Liver, Lung, Placenta, Skin,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 37kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Wnt signaling pathway, Hedgehog signaling pathway, Alzheimer disease, Pathways of neurodegeneration - multiple diseases, Human papillomavirus infection, Breast cancer, Hepatocellular carcinoma, Gastric cancer\u003c\/p\u003e\n\n\u003cp\u003eFunction: Catalytic Activity: ATP + a protein = ADP + a phosphoprotein\u003cbr\u003e\nFunction: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily\u003cbr\u003e\nSimilarity: Belongs to the protein kinase superfamily. CK1 Ser\/Thr protein kinase family. Casein kinase I subfamily\u003cbr\u003e\nSimilarity: Contains 1 protein kinase domain\u003cbr\u003e\nSubunit: Monomer. Interacts with the Axin complex\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Chromosome, centromere, kinetochore Nucleus speckle Cytoplasm, cytoskeleton, cilium basal body Cytoplasm, cytoskeleton, spindle Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis Also recruited to the keratin cytoskeleton (PubMed:23902688)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CSNK1A1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Casein kinase I isoform alpha\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 113927\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P97633\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313508962483,"sku":"ES4857-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313508995251,"sku":"ES4857-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/casein-kinase-i%ce%b1-phospho-tyr294-rabbit-polyclonal-antibody-es4857","provider":"AFSBio Inc.","version":"1.0","type":"link"}