{"product_id":"casein-kinase-iα-rabbit-pab-es1847","title":"Casein Kinase Iα rabbit pAb - ES1847","description":"\u003cp\u003eCasein Kinase Iα rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1847-50, ES1847-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 on 'Ser-45'., similarity:Belongs to the protein kinase superfamily., similarity:Belongs to the protein kinase superfamily. CK1 Ser\/Thr protein kinase family. Casein kinase I subfamily., similarity:Contains 1 protein kinase domain., subunit:Monomer. Interacts with the Axin complex.,\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CKI-alpha. AA range:126-175\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 35kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 1452\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P48729\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688).\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202040586419,"sku":"ES1847-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202040619187,"sku":"ES1847-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_2261d227-ced4-4c94-be70-34446fb58dd2.png?v=1767120494","url":"https:\/\/afsbio.com\/products\/casein-kinase-i%ce%b1-rabbit-pab-es1847","provider":"AFSBio Inc.","version":"1.0","type":"link"}