{"product_id":"casein-kinase-igamma2-polyclonal-antibody-bt-ap01185","title":"Casein Kinase IGamma2 Polyclonal Antibody - BT-AP01185","description":"\u003cp\u003eCasein Kinase IGamma2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01185-20, BT-AP01185-50, BT-AP01185-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Serine\/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP\/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP\/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CSNK1G2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Casein Kinase Igamma2 Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 47457\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P78368; Mouse: Q8BVP5; Rat: Q62762\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CSNK1G2; CK1G2; Casein kinase I isoform gamma-2; CKI-gamma 2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 1455; Mouse: 103236; Rat: 65278\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240157470899,"sku":"BT-AP01185-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240157503667,"sku":"BT-AP01185-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240157536435,"sku":"BT-AP01185-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_13eda13e-c528-4a3a-8ef8-8debae4cd465.png?v=1769404328","url":"https:\/\/afsbio.com\/products\/casein-kinase-igamma2-polyclonal-antibody-bt-ap01185","provider":"AFSBio Inc.","version":"1.0","type":"link"}