{"product_id":"caspase-12-polyclonal-antibody-e-ab-64000","title":"Caspase-12 Polyclonal Antibody - E-AB-64000","description":"\u003cp\u003eCaspase-12 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-64000-60, E-AB-64000-120, E-AB-64000-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Caspase-12\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CASP12; CASP-12; CASP12P1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology,Metabolism,Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q6UXS9\u003c\/p\u003e\n\n\u003cp\u003eBackground: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Feb 2011]\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human Caspase-12\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 19kDa\/29kDa\/38kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146306977971,"sku":"E-AB-64000-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146307010739,"sku":"E-AB-64000-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146307043507,"sku":"E-AB-64000-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_84876a2d-ed21-4152-b545-4e81966cce5c.png?v=1710293390","url":"https:\/\/afsbio.com\/products\/caspase-12-polyclonal-antibody-e-ab-64000","provider":"AFSBio Inc.","version":"1.0","type":"link"}