{"product_id":"caspase-14-polyclonal-antibody-e-ab-61201","title":"Caspase-14 Polyclonal Antibody - E-AB-61201","description":"\u003cp\u003eCaspase-14 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-61201-60, E-AB-61201-120, E-AB-61201-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Caspase-14\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CASP14; ARCI12\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer,Cell Biology\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P31944\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Caspase-14\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 27kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 28-29kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146156114099,"sku":"E-AB-61201-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146156146867,"sku":"E-AB-61201-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146156179635,"sku":"E-AB-61201-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_40fd2e3f-5025-406d-bc10-4754120b5258.png?v=1710291291","url":"https:\/\/afsbio.com\/products\/caspase-14-polyclonal-antibody-e-ab-61201","provider":"AFSBio Inc.","version":"1.0","type":"link"}