{"product_id":"caspase-3-phospho-ser150-polyclonal-antibody-ra22733","title":"Caspase-3 (phospho Ser150) Polyclonal Antibody - RA22733","description":"Caspase-3 (phospho Ser150) Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA22733-50, RA22733-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: caspase 3 (CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\n\nAlternative Names: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 836\n\nProtein MW (KDa): 34\n\nSWISS: P42574\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121147535539,"sku":"RA22733-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121147568307,"sku":"RA22733-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_d68c7e00-906b-4f8a-b57f-2ee7ced0d1c8.png?v=1773371549","url":"https:\/\/afsbio.com\/products\/caspase-3-phospho-ser150-polyclonal-antibody-ra22733","provider":"AFSBio Inc.","version":"1.0","type":"link"}