{"product_id":"caspase-3-polyclonal-antibody-e-ab-66940","title":"Caspase-3 Polyclonal Antibody - E-AB-66940","description":"Caspase-3 Polyclonal Antibody\n\nSizes: 60μL, 120μL, 200μL\n\nCatalogue Numbers: E-AB-66940-60, E-AB-66940-120, E-AB-66940-200\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Caspase-3\n\nTarget Synonym: CPP32; CPP32B; SCA-1; Active Caspase 3; CASP3; active Caspase-3; Caspase 3; Caspase-3 p12; caspase-3\n\nResearch Areas: Cancer, Cell Biology, Metabolism, Neuroscience\n\nConjugation: Unconjugated\n\nHost: Rabbit\n\nSpecies Reactivity: Human, Mouse, Rat\n\nApplication: WB, IHC, IF\n\nIsotype: IgG\n\nClonality: Polyclonal\n\n \n\nUNIProt ID: P42574\n\nBackground: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.\n\nConcentration: 1mg\/mL\n\nImmunogen: Recombinant protein of human Caspase-3.\n\nBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\n\nPurification Method: Affinity purification\n\nDilution: WB \t1:500-1:2000   IHC \t1:50-1:200   IF \t1:50-1:200\n\nCalculated MW: 31kDa\n\nObserved MW: 31kDa\n\nStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\n\nShipping: Ice bag\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146431889587,"sku":"E-AB-66940-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146431922355,"sku":"E-AB-66940-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146431955123,"sku":"E-AB-66940-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_0ac0347e-85c7-42b2-ac38-fe5732345f12.png?v=1710295475","url":"https:\/\/afsbio.com\/products\/caspase-3-polyclonal-antibody-e-ab-66940","provider":"AFSBio Inc.","version":"1.0","type":"link"}