{"product_id":"caspase-9-polyclonal-antibody-bs90193","title":"Caspase-9 Polyclonal Antibody-BS90193","description":"\u003cp\u003eCaspase-9 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90193-50, BS90193-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P55211(Human) Q8C3Q9(Mouse)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB IP\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000-1:2,000\u003c\/p\u003e\n\n\u003cp\u003eBackground: A unique family of cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, Ced-3\/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. Ced-3\/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins, which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of Caspase-9 on differentLysates using anti-Caspase-9 antibody at 1\/1,000 dilution. Positive control:\u003cbr\u003e\n Lane 1: Jurkat\u003cbr\u003e\n Lane 2: Hela\u003cbr\u003e\n Lane 3: C2C12\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight:  46\/39\/37\/35 kDa\u003c\/p\u003e \n\n\u003cp\u003eSpecificity: Caspase-9 polyclonal antibody detects endogenous levels of Caspase-9 protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CASP-9, APAF-3, ICE-LAP6, CASP9, APAF-3, APAF3, Apoptosis related cysteine peptidase, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, CASP-9, CASP9, CASP9, Caspase 9 apoptosis related cysteine peptidase, Caspase 9 Dominant Negative, Caspase 9c, Caspase-9, Caspase-9 subunit p10, ICE LAP6, ICE like apoptotic protease 6, ICE-LAP6, ICE-like apoptotic protease 6, MCH6, PPP1R56, protein phosphatase 1, regulatory subunit 56, RNCASP9,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939198242995,"sku":"BS90193-50","price":415.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939198275763,"sku":"BS90193-100","price":640.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_12446e78-8773-4f3e-aa16-3f95882e0695.jpg?v=1704544949","url":"https:\/\/afsbio.com\/products\/caspase-9-polyclonal-antibody-bs90193","provider":"AFSBio Inc.","version":"1.0","type":"link"}