{"product_id":"caspr2-cntnap2-polyclonal-antibody-e-ab-92775","title":"Caspr2\/CNTNAP2 Polyclonal Antibody - E-AB-92775","description":"\u003cp\u003eCaspr2\/CNTNAP2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92775-60, E-AB-92775-120, E-AB-92775-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Caspr2\/CNTNAP2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CNTNAP2; AUTS15; CASPR2; CDFE; NRXN4; PTHSL1\u003c\/p\u003e\n\n \n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UHC6\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5\/8 type C domain, discoidin\/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human Caspr2\/Caspr2\/CNTNAP2\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 11kDa\/148kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 160kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43145962815667,"sku":"E-AB-92775-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43145962848435,"sku":"E-AB-92775-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43145962881203,"sku":"E-AB-92775-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_22bfb376-45d1-4718-b0f5-5a29bfbc2b63.png?v=1710288912","url":"https:\/\/afsbio.com\/products\/caspr2-cntnap2-polyclonal-antibody-e-ab-92775","provider":"AFSBio Inc.","version":"1.0","type":"link"}