{"product_id":"casr-a884-polyclonal-antibody-bs1729","title":"CaSR (A884) Polyclonal Antibody-BS1729","description":"\u003cp\u003eCaSR (A884) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1729-50, BS1729-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P41180\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: The calcium sensing receptor (CaSR) has been shown to play\u003cbr\u003e\n a major role in regulating parathyroid hormone secretion and\u003cbr\u003e\n subsequently influencing the calcium concentration of extracellular\u003cbr\u003e\n fluids. Based on sequence analysis of cDNA clones\u003cbr\u003e\n it appears that the CaSR is similar to the 7-transmembranedomain\u003cbr\u003e\n G-protein-coupled receptor superfamily. Changes in\u003cbr\u003e\n extracellular calcium are thought to modulate a balance between\u003cbr\u003e\n proliferation and differentiation in a variety of cell\u003cbr\u003e\n types. In normal primary keratinocytes and breast epithelial\u003cbr\u003e\n cells, proliferation is inhibited and elevated extracellular\u003cbr\u003e\n calcium levels trigger differentiation. Malignant transformations\u003cbr\u003e\n of these cell types are accompanied by a loss of responsiveness\u003cbr\u003e\n to the anti-proliferative effects of elevated extracellular\u003cbr\u003e\n calcium.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Immunohistochemistry (IHC) analyzes of CaSR (A884) pAb in paraffin-embedded human breast carcinoma tissue at 1:50.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 140 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CaSR (A884) polyclonal antibody detects endogenous levels of CaR protein.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor 1; PCaR1; CASR; GPRC2A; PCAR1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 850-900 of Human CaSR.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42939268628659,"sku":"BS1729-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42939268661427,"sku":"BS1729-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7d821c50-85d6-418d-98d7-0099371cbd44.jpg?v=1704545704","url":"https:\/\/afsbio.com\/products\/casr-a884-polyclonal-antibody-bs1729","provider":"AFSBio Inc.","version":"1.0","type":"link"}