{"product_id":"casr-polyclonal-antibody-bt-ap14684","title":"CASR Polyclonal Antibody - BT-AP14684","description":"\u003cp\u003eCASR Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14684-20, BT-AP14684-50, BT-AP14684-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.\u003c\/p\u003e \n\n\u003cp\u003eResearch Areas: Metabolism; Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CASR\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Extracellular calcium-sensing receptor\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P41180; Mouse: Q9QY96; Rat: P48442\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Extracellular calcium-sensing receptor; CASR; GPRC2A; PCAR1; Extracellular calcium-sensing receptor; CaSR; Parathyroid cell calcium-sensing receptor; PCaR1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 846\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239075864755,"sku":"BT-AP14684-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239075897523,"sku":"BT-AP14684-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239075930291,"sku":"BT-AP14684-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_1bdd1be7-4351-43ed-acf7-586977e7d48c.png?v=1769388781","url":"https:\/\/afsbio.com\/products\/casr-polyclonal-antibody-bt-ap14684","provider":"AFSBio Inc.","version":"1.0","type":"link"}