{"product_id":"catenin-β-phospho-t41-s45-polyclonal-antibody-bs4030","title":"Catenin-β (phospho-T41\/S45) Polyclonal Antibody - BS4030","description":"\u003cp\u003eCatenin-β (phospho-T41\/S45) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4030-50, BS4030-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: β-Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β-catenin at Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3β. GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites resμlt in the stabilization of β-catenin protein levels and have been found in many tumor cell lines.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Catenin β, Cateninβ, Catenin beta-1, Beta-catenin, CTNNB1, CTNNB, ORF Names: OK\/SW-cl.35, PRO2286\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A phospho specific peptide corresponding to residues surrounding threonine 41 and 45 of Human Catenin-β.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-Catenin-β (T41+S45) polyclonal antibody detects endogenous levels of Catenin-β protein only when phosphorylated at Thr41+S45 .\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 92 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Hypoxia Signaling, Wntβ catenin signaling，Contribution of ECM and Cytoskeletal Factors to EMT, Contribution of Soluble Factors to EMT, hippo Signaling, Adherens Junction signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P35222\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946271727795,"sku":"BS4030-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946271760563,"sku":"BS4030-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/catenin-%ce%b2-phospho-t41-s45-polyclonal-antibody-bs4030","provider":"AFSBio Inc.","version":"1.0","type":"link"}