{"product_id":"catenin-δ1-phospho-y228-polyclonal-antibody-bs4381","title":"Catenin-δ1  (phospho-Y228)  Polyclonal Antibody - BS4381","description":"\u003cp\u003eCatenin-δ1  (phospho-Y228)  Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4381-50, BS4381-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regμlatory domain containing mμltiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function. Catenin δ-1 fμlfills critical roles in the regμlation of cell-cell adhesion as it regμlates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion. Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion. Actin dynamics are also regμlated by catenin δ-1, which modμlates RhoA, Rac, and cdc42 proteins. Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregμlarly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas), CTNND1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylated\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human Catenin-δ1 around the phosphorylation site of Tyrosine 228\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Catenin-δ1 (phospho-Y228) polyclonal antibody detects endogenous levels of Catenin-δ1 protein only when phosphorylated at Tyr228.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 95,  100 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Contribution of ECM and Cytoskeletal Factors to EMT,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O60716\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946301186227,"sku":"BS4381-50","price":289.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946301218995,"sku":"BS4381-100","price":492.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/catenin-%ce%b41-phospho-y228-polyclonal-antibody-bs4381","provider":"AFSBio Inc.","version":"1.0","type":"link"}