{"product_id":"catenin-delta-1-monoclonal-antibody-mb66235","title":"Catenin delta 1 Monoclonal Antibody - MB66235","description":"\u003cp\u003eCatenin delta 1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66235-50, MB66235-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Catenin δ-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regμlatory domain containing mμltiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function . Catenin δ-1 fμlfills critical roles in the regμlation of cell-cell adhesion as it regμlates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion . Catenin δ-1 has both positive and negative effects on cadherin-mediated adhesion . Actin dynamics are also regμlated by catenin δ-1, which modμlates RhoA, Rac, and cdc42 proteins . Analogous to β-catenin, catenin δ-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin δ-1 is expressed irregμlarly or is absent in various types of tumor cells, suggesting that catenin δ-1 may function as a tumor suppressor\u003c\/p\u003e \n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: KIAA0384, Catenin delta-1, Cadherin-associated Src substrate, CAS, p120 catenin, p120(ctn), p120(cas)\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within human Catenin delta 1. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/100 - 1\/300)\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of Catenin delta 1 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 95, 105 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Adherens Junction signaling, Wntβ catenin signaling,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: O60716\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946397524147,"sku":"MB66235-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946397556915,"sku":"MB66235-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/catenin-delta-1-monoclonal-antibody-mb66235","provider":"AFSBio Inc.","version":"1.0","type":"link"}