{"product_id":"cathepsin-b-polyclonal-antibody-ra22783","title":"Cathepsin B Polyclonal Antibody - RA22783","description":"Cathepsin B Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA22783-50, RA22783-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: cathepsin B (CTSB) Homo sapiens This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP) . Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors.\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/5000. Not yet tested in other applications.\n\nAlternative Names: CTSB; CPSB; Cathepsin B; APP secretase; APPS; Cathepsin B1\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 1508\n\nProtein MW (KDa): 38,40,25\n\nSWISS: P07858\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121156776115,"sku":"RA22783-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121156808883,"sku":"RA22783-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c733062e-3a5a-4f4e-9049-8152b7130f0d.png?v=1773371609","url":"https:\/\/afsbio.com\/products\/cathepsin-b-polyclonal-antibody-ra22783","provider":"AFSBio Inc.","version":"1.0","type":"link"}