{"product_id":"catsper1-polyclonal-antibody-bs60723","title":"CATSPER1 Polyclonal Antibody-BS60723","description":"\u003cp\u003eCATSPER1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60723-50, BS60723-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q8NEC5\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: CatSper is an ion transport protein located on the surface of sperm cells. CatSper (for cation channel of sperm) is vital to cAMP-mediated calcium influx in sperm, sperm motility and fertilization. The gene that encodes CatSper maps to human chromosome 11q12.1. The 686 amino acid protein is a single, six-transmembrane-spanning protein of the voltage- dependent Ca2+ channel four-repeat structure and is expressed exclusively in the testis. In CatSper -\/- sperm, neither cAMP nor cGMP elicit a significant Ca2+ influx in both mutant and wild-type sperm. CatSper is localized to the sperm flagellum and CatSper -\/- mice show sluggish and less directed movements. CatSper is required to penetrate the egg, but is not required for egg activation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CATSPER1 polyclonal antibody detects endogenous levels of CATSPER1 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 90 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CATSPER1 polyclonal antibody at 1:1000 dilution\u003cbr\u003e\n Lane 1: A549 whole cell lysate\u003cbr\u003e\n Lane 2: Hela whole cell lysate \u003cbr\u003e\n Lane 3: SP2\/0 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cation channel sperm-associated protein 1; CatSper1; hCatSper; CATSPER1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide corresponding to residues in Human CATSPER1\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42987092115635,"sku":"BS60723-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42987092148403,"sku":"BS60723-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_67bd456b-1185-474c-89f2-6a0470a84a4f.jpg?v=1706008987","url":"https:\/\/afsbio.com\/products\/catsper1-polyclonal-antibody-bs60723","provider":"AFSBio Inc.","version":"1.0","type":"link"}