{"product_id":"cavα2δ2-rabbit-pab-es20792","title":"CaVα2δ2 rabbit pAb - ES20792","description":"\u003cp\u003eCaVα2δ2 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES20792-50, ES20792-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: calcium voltage-gated channel auxiliary subunit alpha2delta 2 (CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2\/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2\/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation\/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to\u003c\/p\u003e\n\n\u003cp\u003eAlternate Name: Voltage-dependent calcium channel subunit alpha-2\/delta-2 (Voltage-gated calcium channel subunit alpha-2\/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; IHC; IF\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide of CaVα2δ2 AA range: 540-620\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 100-120kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 9254\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9NY47\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Membrane; Single-pass type I membrane protein. Colocalizes with CACNA1A in lipid raft fractions.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202436653235,"sku":"ES20792-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202436686003,"sku":"ES20792-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_bb5163b3-1662-4cf2-b95d-36350649bb6b.png?v=1767129123","url":"https:\/\/afsbio.com\/products\/cav%ce%b12%ce%b42-rabbit-pab-es20792","provider":"AFSBio Inc.","version":"1.0","type":"link"}