{"product_id":"cavalpha2delta2-polyclonal-antibody-bt-ap07173","title":"CaVAlpha2delta2 Polyclonal Antibody - BT-AP07173","description":"\u003cp\u003eCaVAlpha2delta2 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP07173-20, BT-AP07173-50, BT-AP07173-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2\/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2\/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation\/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Neuroscience; Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CACNA2D2\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC-p, IF\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Voltage-dependent calcium channel subunit alpha-2\/delta-2\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q9NY47; Mouse: Q6PHS9; Rat: Q8CFG6\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Voltage-dependent calcium channel subunit alpha-2\/delta-2;Voltage-gated calcium channel subunit alpha-2\/delta-2 [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent; Voltage-dependent calcium channel subunit alpha-2\/delta-2; Voltage-gated calcium channel subunit alpha-2\/delta-2; Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2;\u003c\/p\u003e \n\n\u003cp\u003eGeneID: Human: 9254\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239077109939,"sku":"BT-AP07173-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239077142707,"sku":"BT-AP07173-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239077175475,"sku":"BT-AP07173-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_a5c79cc3-9f89-4f3b-915f-fb66cd888434.png?v=1769388797","url":"https:\/\/afsbio.com\/products\/cavalpha2delta2-polyclonal-antibody-bt-ap07173","provider":"AFSBio Inc.","version":"1.0","type":"link"}