{"product_id":"cb1-rabbit-polyclonal-antibody-es4723","title":"CB1 Rabbit Polyclonal Antibody - ES4723","description":"\u003cp\u003eCB1 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES4723-50, ES4723-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CNR1, CNR, Cannabinoid receptor 1, CB-R, CB1, CANN6\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CNR1. AA range:151-200\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CB1\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CB1 Polyclonal Antibody detects endogenous levels of CB1 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. Immunofluorescence: 1\/200 - 1\/1000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Widely expressed, with highest levels in fetal and adult brain, Expression levels of isoform 2 and isoform 3 are much lower than those of isoform 1,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 53kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endocannabinoid signaling\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding\u003cbr\u003e\nSimilarity: Belongs to the G-protein coupled receptor 1 family\u003cbr\u003e\nSubunit: Interacts (via C-terminus) with CNRIP1\u003cbr\u003e\nTissue Specificity: Widely expressed\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Cell membrane, Multi-pass membrane protein Membrane raft Mitochondrion outer membrane Cell projection, axon Cell junction, synapse, presynapse Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity) Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity)\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CNR1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Cannabinoid receptor 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 12801\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: P47746\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 25248\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: P20272\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313494413491,"sku":"ES4723-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313494446259,"sku":"ES4723-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/cb1-rabbit-polyclonal-antibody-es4723","provider":"AFSBio Inc.","version":"1.0","type":"link"}