{"product_id":"ccl2-mcp-1-rabbit-pab-a7277","title":"CCL2\/MCP-1 Rabbit pAb - A7277","description":"CCL2\/MCP-1 Rabbit pAb\n\nSizes: 20μL, 100μL\n\nCatalogue Numbers: A7277-20, A7277-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS\u0026amp;#8208;CoV\u0026amp;#8208;2) infection.\n\nCategory: Polyclonal Antibodies\n\nApplications: WB, IHC-P, ELISA\n\nCross-reactivity: Human, Mouse, Rat\n\nProtein Weight: 11kDa\n\nObserved Molecular Weight: 13-15kDa\n\nImmunogen: Recombinant protein (or fragment) .\n\nSpecies: Human\n\nGeneID: 6347\n\nSWISS: P13500\n\nAlternate Names: HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30; CCL2\/MCP-1\n\nSource: Rabbit\n\nIsotype: IgG\n\nPurity: Affinity purification\n\nStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.09% Sodium azide, 50% glycerol, pH 7.3.\n\nRecommended Dilutions: WB, 1:1000 - 1:5000 IHC-P, 1:50 - 1:200 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\n\nResearch Areas: Cancer, Signal Transduction, Kinase, Cell Biology Developmental Biology, Apoptosis, Endocrine Metabolism, Immunology Inflammation, Cytokines, Cell Intrinsic Innate Immunity Signaling Pathway, Cardiovascular, Hypoxia, Heart, Cardiovascular diseases, Heart disease.\n\nNCBI Alias: CCL2\n\nResearch Use Only","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45190029246643,"sku":"A7277-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45190029279411,"sku":"A7277-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_7d880054-baf9-490f-b10e-ef7540d4f9d0.png?v=1766440254","url":"https:\/\/afsbio.com\/products\/ccl2-mcp-1-rabbit-pab-a7277","provider":"AFSBio Inc.","version":"1.0","type":"link"}