{"product_id":"ccr4-polyclonal-antibody-bs60964","title":"CCR4 Polyclonal Antibody-BS60964","description":"\u003cp\u003eCCR4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS60964-50, BS60964-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CCR4; CMKBR4\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P51679\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: C-C or β chemokine family members are characterized by a pair of adjacent\u003cbr\u003e\ncysteine residues and serve as potentchemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1,CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7 and the Duffy blood group antigen. Each of these receptors are G protein-coupled,seven pass\u003cbr\u003e\ntransmembrane domain proteins whose major physiological role is to function\u003cbr\u003e\nin the chemotaxis of T cells and phagocytic cells to areas of inflammation.\u003cbr\u003e\nHowever, this receptor family has also been shown to facilitate viral infection.\u003cbr\u003e\nCKR-4 (C-C chemokine receptor type 4), also known as CCR4 or CMKBR4, is\u003cbr\u003e\na 360 amino acidmulti-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family. Expressed at high levels in peripheral blood leukocytes and thymustissue, CKR-4 functions as a high affinity receptor for C-C type chemokines and is thought to be involved\u003cbr\u003e\nin hippocampal-neuron survival.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CCR4 polyclonal antibody detects endogenous levels of CCR4 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 41 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CCR4 polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: HEK293T whole cell lysate\u003cbr\u003e\nLane 2: NIH-3T3 whole cell lysate\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide corresponding to residues in Human CCR4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42913804255411,"sku":"BS60964-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42913804288179,"sku":"BS60964-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_5c55ee03-b404-4ce6-b16b-e2aec031e294.jpg?v=1703267062","url":"https:\/\/afsbio.com\/products\/ccr4-polyclonal-antibody-bs60964","provider":"AFSBio Inc.","version":"1.0","type":"link"}