{"product_id":"cd109-polyclonal-antibody-ncp0172p","title":"CD109 Polyclonal Antibody-NCP0172P","description":"\u003cp\u003eCD109 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: NCP0172P-50, NCP0172P-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q6YHK3\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000~1:2000\u003cbr\u003e\nIF  1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic\/prognostic marker for several types of cancers.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD109 polyclonal antibody detects endogenous levels of CD109 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 180 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CD109 polyclonal antibody at 1:1000 dilution\u003cbr\u003e\n Lane 1: A549 cell membrane lysate (24ug)\u003cbr\u003e\n Lane 2: A375 whole cell lysate (24ug), Immunofluorescence analysis of A549 cells using CD109 pAb at dilution of 1:200.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CD109 antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; Platelet-specific Gov antigen; p180; r150; CD109; CPAMD7\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human CD109.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42989584220339,"sku":"NCP0172P-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42989584253107,"sku":"NCP0172P-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_96ef84ea-c870-4b92-84ad-fab5a13f4e3e.jpg?v=1706095772","url":"https:\/\/afsbio.com\/products\/cd109-polyclonal-antibody-ncp0172p","provider":"AFSBio Inc.","version":"1.0","type":"link"}