{"product_id":"cd117-kit-recombinant-protein-ncp0253","title":"CD117\/KIT Recombinant Protein - NCP0253","description":"\u003cp\u003eCD117\/KIT Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0253-500, NCP0253-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P10721\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: CAGCCTAGTGTTAGCCCGGGTGAACCGAGCCCGCCGAGCATTCATCCGGGCAAAAGCGATCTGATTGTTCGTGTTGGTGATGAAATTCGTCTGCTGTGCACCGATCCGGGCTTCGTGAAATGGACCTTCGAAATTCTGGATGAAACCAATGAAAATAAGCAGAATGAATGGATTACCGAAAAAGCAGAAGCCACCAATACCGGCAAATATACCTGCACCAATAAACATGGTCTGAGTAATAGTATCTATGTGTTCGTTCGCGATCCGGCCAAACTGTTCCTGGTGGATCGTAGCCTGTATGGTAAAGAAGATAATGATACCCTGGTGCGCTGTCCGCTGACCGATCCGGAAGTTACCAATTATAGTCTGAAAGGTTGCCAGGGCAAACCGCTGCCGAAAGATCTGCGCTTCATTCCGGATCCGAAAGCAGGCATTATGATTAAAAGCGTTAAACGCGCATATCATCGTCTGTGTCTGCATTGCAGCGTGGATCAGGAAGGTAAAAGTGTTCTGAGCGAAAAATTCATTCTGAAAGTGCGCCCGGCATTCAAAGCAGTTCCGGTTGTGAGCGTGAGTAAAGCAAGTTATCTGCTGCGCGAAGGCGAAGAATTCACCGTGACCTGTACCATTAAAGATGTGAGTAGCAGCGTGTATAGTACCTGGAAACGTGAAAATAGTCAGACCAAACTGCAGGAAAAATATAATAGTTGGCATCATGGTGACTTCAATTATGAACGTCAGGCCACCCTGACCATTAGCAGCGCCCGCGTTAATGATAGCGGCGTGTTCATGTGTTATGCAAATAATACCTTCGGTAGCGCCAATGTGACCACCACCCTGGAAGTTGTGGATAAAGGCTTCATTAATATCTTCCCGATGATTAATACCACCGTGTTCGTGAATGATGGTGAAAATGTGGATCTGATTGTGGAATATGAAGCATTCCCGAAACCGGAACATCAGCAGTGGATCTATATGAATCGCACCTTCACCGATAAATGGGAAGATTATCCGAAAAGCGAAAATGAAAGCAATATTCGTTACGTGAGTGAACTGCATCTGACCCGCCTGAAAGGCACCGAAGGCGGCACCTATACCTTCCTGGTGAGTAATAGCGATGTGAATGCAGCAATTGCCTTCAATGTGTATGTGAATACCAAACCGGAAATTCTGACCTATGATCGCCTGGTGAATGGCATGCTGCAGTGCGTTGCAGCCGGCTTCCCGGAACCGACCATTGATTGGTACTTCTGCCCGGGTACCGAACAGCGTTGTAGCGCCAGTGTGCTGCCGGTGGATGTTCAGACCCTGAATAGCAGCGGCCCGCCGTTCGGTAAACTGGTTGTTCAGAGCAGTATTGATAGTAGTGCCTTCAAACATAATGGCACCGTGGAATGCAAAGCCTATAATGATGTGGGTAAAACCAGCGCATACTTCAACTTCGCCTTCAAAGGTAATAATAAAGAACAGATTCACCCGCATACCCTGTTCACCCCG\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3\/flk-2 receptors. It plays a critical role in activation and growth in a number of cell types including hematopoietic stem cells, mast cells, melanocytes, and germ cells. Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization\/oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders, and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors. Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~55kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887062978739,"sku":"NCP0253-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887063011507,"sku":"NCP0253-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_46016d16-f225-43e5-843e-520dec85a997.jpg?v=1702317329","url":"https:\/\/afsbio.com\/products\/cd117-kit-recombinant-protein-ncp0253","provider":"AFSBio Inc.","version":"1.0","type":"link"}