{"product_id":"cd117-monoclonal-antibody-mb66859","title":"CD117 Monoclonal Antibody - MB66859","description":"\u003cp\u003eCD117 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66859-50, MB66859-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: c-Kit is a member of the subfamily of receptor tyrosine kinases that includes PDGF, CSF-1, and FLT3\/flk-2 receptors . It plays a critical role in activation and growth in a number of cell types, including hematopoietic stem cells, mast cells, melanocytes, and germ cells . Upon binding with its stem cell factor (SCF) ligand, c-Kit undergoes dimerization\/oligomerization and autophosphorylation. Activation of c-Kit resμlts in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components, including PLCγ, the p85 subunit of PI3 kinase, SHP2, and CrkL . Molecμlar lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders , and mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors . Tyr719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\/ICC\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: SCFR, Mast\/stem cell growth factor receptor Kit, SCFR, Piebald trait protein, PBT, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human CD117. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000), IHC (1\/50 - 1\/200), IF\/ICC (1\/10 - 1\/50)\u003c\/p\u003e\n\n\u003cp\u003ePurification: This antibody is purified through a protein G column.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of CD117 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 110 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Signaling Pathways Activating p38 MAP Kinase\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P10721\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgM. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946422067379,"sku":"MB66859-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946422100147,"sku":"MB66859-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/cd117-monoclonal-antibody-mb66859","provider":"AFSBio Inc.","version":"1.0","type":"link"}