{"product_id":"cd119-polyclonal-antibody-ncp0255p","title":"CD119 Polyclonal Antibody-NCP0255P","description":"\u003cp\u003eCD119 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: NCP0255P-50, NCP0255P-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P15260\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:1000~1:2000\u003cbr\u003e\nIF  1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Receptor subunit for interferon gamma\/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation Associates with transmembrane accessory factor IFNGR2 to form a functional receptor.Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription.STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity).\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD119 polyclonal antibody detects endogenous levels of CD119 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 45-90 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CD119 polyclonal antibody at 1:1000 dilution\u003cbr\u003e\n Lane 1: The Liver tissue lysate of Rat (30ug)\u003cbr\u003e\n Lane 2: SP2\/0 cell membrane lysate (30ug)\u003cbr\u003e\n Lane 3: HepG2 whole cell lysate (30ug)\u003cbr\u003e\n Lane 4: MCF-7 cell membrane lysate (30ug), Immunofluorescence analysis of MCF-7 cells using CD119 pAb at dilution of 1:200.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Interferon gamma receptor 1; IFN-gamma receptor; IFN-gamma-R1; CDw119; Interferon gamma receptor alpha-chain; IFN-gamma-R-alpha; CD119\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human CD119.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42989585727667,"sku":"NCP0255P-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42989585760435,"sku":"NCP0255P-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_bd4a6003-c47d-4a49-a110-23ce487f1c3e.jpg?v=1706095814","url":"https:\/\/afsbio.com\/products\/cd119-polyclonal-antibody-ncp0255p","provider":"AFSBio Inc.","version":"1.0","type":"link"}