{"product_id":"cd137-rat-monoclonal-antibody-mb65858","title":"CD137 Rat Monoclonal Antibody-MB65858","description":"\u003cp\u003eCD137 Rat Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:MB65858-50, MB65858-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rat IgG2a. Liquid in PBS, pH 7.3, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P20334\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNFRSF9 is a member of the tumor necrosis factor receptor superfamily. It is also called 4-1BB or CD137. 4-1BB\/CD137\/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells. The ligand 4-1BBL\/CD137L\/TNFSF9 on antigen presenting cells binds to 4-1BB\/CD137\/TNFRSF9 and costimulates the activation of T cells. The binding of agonistic antibodies to 4-1BB\/CD137\/TNFRSF9 also leads to costimulation for T cell activation. Studies have shown the effectiveness of targeting 4-1BB\/CD137\/TNFRSF9 by its agonistic antibodies in cancer immunotherapy.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from Rat antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 27 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes mouse CD137\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: CD137; ILA; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD137\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Mouse CD137 human Fc fusion protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895057944755,"sku":"MB65858-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895057977523,"sku":"MB65858-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b55a58d0-6873-4bd9-adf9-04ff8940c6ed.jpg?v=1702573135","url":"https:\/\/afsbio.com\/products\/cd137-rat-monoclonal-antibody-mb65858","provider":"AFSBio Inc.","version":"1.0","type":"link"}