{"product_id":"cd146-mcam-polyclonal-antibody-e-ab-92375","title":"CD146\/MCAM Polyclonal Antibody - E-AB-92375","description":"\u003cp\u003eCD146\/MCAM Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-92375-60, E-AB-92375-120, E-AB-92375-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD146\/MCAM\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MCAM; CD146; MUC18; cell surface glycoprotein MUC18\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cardiovascular, Immunology, Signal Transduction, Stem Cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P43121\u003c\/p\u003e\n\n\u003cp\u003eBackground: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2\/FAK1, and a transient increase in the intracellular calcium concentration.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein of human CD146\/MCAM\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 57kDa\/71kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 120KDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146633281715,"sku":"E-AB-92375-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146633314483,"sku":"E-AB-92375-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146633347251,"sku":"E-AB-92375-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_40bdbfc9-dc3e-427e-904f-539a131f32c5.png?v=1710298935","url":"https:\/\/afsbio.com\/products\/cd146-mcam-polyclonal-antibody-e-ab-92375","provider":"AFSBio Inc.","version":"1.0","type":"link"}