{"product_id":"cd148-monoclonal-antibody-bt-mca2114","title":"CD148 Monoclonal Antibody - BT-MCA2114","description":"\u003cp\u003eCD148 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2114-50, BT-MCA2114-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD148\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6F2E12\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CD148\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CD148 (AA: extra 36-210) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 146kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q12913\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: PTPRJ, DEP1, SCC1, HPTPeta, R-PTP-ETA\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5795\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238535684275,"sku":"BT-MCA2114-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238535717043,"sku":"BT-MCA2114-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_526c3493-6128-4ad4-9544-7c66c087841e.png?v=1769382327","url":"https:\/\/afsbio.com\/products\/cd148-monoclonal-antibody-bt-mca2114","provider":"AFSBio Inc.","version":"1.0","type":"link"}