{"product_id":"cd158a-polyclonal-antibody-ncp0282p","title":"CD158a Polyclonal Antibody-NCP0282P","description":"CD158a Polyclonal Antibody\n\nCatalogue Numbers: NCP0282P-50, NCP0282P-100\n\nSizes: 50µl, 100µl\n\nProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\n\nSwiss-Prot: P43626\n\nHost: Rabbit\n\nReactivity: Human, Mouse\n\nApplications: WB\n\nAll Applications: WB: 1:5000~1:10000\n\nBackground: NKAT (NK-associated transcripts) gene products, known as killer immunoglobulin-like receptors or KIRs, downregulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. This family of receptors is characterized by an extracellular region with two to three immunoglobulin-superfamily domains and a cytoplasmic domain with an antigen receptor activation motif (ARAM). KIRs and other inhibitory receptors also possess a common cytoplasmic sequence (I\/VxYxxL\/V) known as an ITIM (immunoreceptor tyrosine-based inhibitory motif). The human inhibitory natural killer cell immunoglobulin-like receptor 2DL1, also designated KIR2DL1, CL-42, NKAT1, P58.1 or CD158a long form, is a 348 amino acid type I transmembrane protein. KIR2DL1 can bind human leukocyte antigen-C (HLA-C) via both polar and hydrophobic interactions through Met 44 in a binding pocket that coordinates Lys 80 of HLA-C.\n\nPurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nSpecificity: CD158a polyclonal antibody detects endogenous levels of CD158a protein.\n\nExtra Notes: Western blot (WB) analysis of CD158a polyclonal antibody at 1:5000 dilution\nLane1:The Heart tissue lysate of Mouse(15ug)\nLane2:L02 cell membrane lysate(24ug)\nLane3:MCF-7 cell membrane lysate(24ug)\n\nBioworld Molecular Weight: ~ 49 kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nAlternative Name: Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42\/47.11; p58 NK receptor CL-42\/47.11; p58.1 MHC class-I-specific NK receptor; CD158a; KIR2DL1; CD158A; NKAT1\n\nImmunogen: Recombinant protein of human CD158a.\n\nConjugate: Unconjugated\n\nModification: Unmodified","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908702638259,"sku":"NCP0282P-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908702671027,"sku":"NCP0282P-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_7fd974a7-b8e4-4d5a-b8fb-14acc6ef013b.jpg?v=1703006009","url":"https:\/\/afsbio.com\/products\/cd158a-polyclonal-antibody-ncp0282p","provider":"AFSBio Inc.","version":"1.0","type":"link"}