{"product_id":"cd158b2-j-polyclonal-antibody-ra22937","title":"CD158b2\/j Polyclonal Antibody - RA22937","description":"CD158b2\/j Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA22937-50, RA22937-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 (KIR2DL3) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes, although several \"framework\" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\n\nAlternative Names: KIR2DL3; CD158B2; KIRCL23; NKAT2; Killer cell immunoglobulin-like receptor 2DL3; CD158 antigen-like family member B2; KIR-023GB; Killer inhibitory receptor cl 2-3; MHC class I NK cell receptor; NKAT2a; NKAT2bNatural killer-associated transcript 2; NKAT-2; p58 natural killer cell receptor clone CL-6; p58 NK receptor CL-6; p58.2 MHC class-I-specific NK receptor; CD158b2; KIR2DS2; CD158J; NKAT5; Killer cell immunoglobulin-like receptor 2DS2;\n\nApplications: WB; ELISA\n\nSpecies Cross-Reactivity: Human; Rat; Mouse\n\nGeneID (Human): 3804\/100132285\n\nProtein MW (KDa): 38\n\nSWISS: P43628\/P43631\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121177977011,"sku":"RA22937-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121178009779,"sku":"RA22937-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c904eb94-bb76-4dee-b131-2a61f0b95647.png?v=1773371740","url":"https:\/\/afsbio.com\/products\/cd158b2-j-polyclonal-antibody-ra22937","provider":"AFSBio Inc.","version":"1.0","type":"link"}