{"product_id":"cd161-polyclonal-antibody-ncp0285p","title":"CD161 Polyclonal Antibody-NCP0285P","description":"\u003cp\u003eCD161 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: NCP0285P-50, NCP0285P-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q12918\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Rat, Mouse, Human,\u003c\/p\u003e \n\n\u003cp\u003eApplications: WB, IF\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:5000~1:10000\u003cbr\u003e\nIF  1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase\/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1\/PKB and RPS6KA1\/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D\/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD161 polyclonal antibody detects endogenous levels of CD161 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 43 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CD161 polyclonal antibody at 1:5000 dilution\u003cbr\u003e\n Lane 1: HEK293T cell membrane lysate (30ug)\u003cbr\u003e\n Lane 2: MCF-7 cell membrane lysate (30ug)\u003cbr\u003e\n Lane 3: CT-26 whole cell lysate (30ug)\u003cbr\u003e\n Lane 4: PC12 whole cell lysate (30ug), Immunofluorescence analysis of HEK293T cells using CD161 pAb at dilution of 1:200.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a; NKR-P1A; Natural killer cell surface protein P1A; CD161\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human CD161.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42989588840627,"sku":"NCP0285P-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42989588873395,"sku":"NCP0285P-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3bb14150-746c-4734-b05c-e35927bda2b5.jpg?v=1706095824","url":"https:\/\/afsbio.com\/products\/cd161-polyclonal-antibody-ncp0285p","provider":"AFSBio Inc.","version":"1.0","type":"link"}