{"product_id":"cd169-polyclonal-antibody-ncp0291p","title":"CD169 Polyclonal Antibody-NCP0291P","description":"CD169 Polyclonal Antibody\n\nCatalogue Numbers: NCP0291P-50, NCP0291P-100\n\nSizes: 50µl, 100µl\n\nProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\n\nSwiss-Prot: Q9BZZ2\n\nHost: Rabbit\n\nReactivity: Human, Rat, Mouse\n\nApplications: WB\n\nAll Applications: WB: 1:1000~1:2000\n\nBackground: Two families of mammalian lectin-like adhesion molecules, the selectins and the sialoadhesins, bind glycoconjugate ligands in a sialic acid-dependent manner. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members that recognize sialylated ligands. The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). The human Siglec-1 gene maps to chromosome 20p13 and encodes a 1,709 amino acid protein, also known as CD169. Alternative splicing of the Siglec-1 gene produces a variant, encoding a type I transmembrane protein isoform that is soluble rather than membrane-bound. Studies have shown human Siglec-1 has greater affinity for Neu5Ac over Neu5Gc. Siglec-1 is a sialic acid-binding receptor that is expressed in hemopoietic cells. It mediates local cell-cell interactions in lymphoid tissues and can be detected at contact points of macrophages with other macrophages, sinus-lining cells and reticulum cells.\n\nPurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\n\nStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\n\nSpecificity: CD169 polyclonal antibody detects endogenous levels of CD169 protein.\n\nExtra Notes: Western blot (WB) analysis of CD169 polyclonal antibody at 1:1000 dilution\nLane1:RAW264.7 whole cell lysate(30ug)\nLane2:Myla2059 whole cell lysate(30ug)\nLane3:The Spleen tissue lysate of Rat(30ug)\n\nBioworld Molecular Weight: ~ 200 kDa\n\nNote: For research use only, not for use in diagnostic procedure.\n\nAlternative Name: Sialoadhesin; Sialic acid-binding Ig-like lectin 1; Siglec-1; CD169; SIGLEC1; SN\n\nImmunogen: Recombinant protein of human CD169.\n\nConjugate: Unconjugated\n\nModification: Unmodified","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908700737715,"sku":"NCP0291P-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908700770483,"sku":"NCP0291P-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_fc139bc5-f66c-4739-aa94-d3f0b1e98a70.jpg?v=1703005985","url":"https:\/\/afsbio.com\/products\/cd169-polyclonal-antibody-ncp0291p","provider":"AFSBio Inc.","version":"1.0","type":"link"}