{"product_id":"cd1b-recombinant-protein-ncp0186","title":"CD1B Recombinant Protein - NCP0186","description":"\u003cp\u003eCD1B Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0186-500, NCP0186-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P29016\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: AGTGAACATGCATTCCAGGGCCCGACCAGCTTCCATGTGATTCAGACCAGTAGCTTCACCAATAGTACCTGGGCACAGACCCAGGGCAGCGGTTGGCTGGATGATCTGCAGATTCATGGTTGGGATAGTGATAGTGGCACCGCCATCTTCCTGAAACCGTGGAGTAAAGGCAACTTCAGCGATAAAGAAGTTGCAGAACTGGAAGAAATCTTCCGTGTGTATATCTTCGGCTTCGCCCGCGAAGTTCAGGACTTCGCCGGCGACTTCCAGATGAAATATCCGTTCGAAATTCAGGGCATTGCCGGCTGTGAACTGCATAGCGGCGGTGCCATTGTTAGCTTCCTGCGCGGCGCCCTGGGCGGTCTTGACTTCCTGAGCGTTAAAAATGCCAGTTGCGTGCCGAGCCCGGAAGGCGGTAGTCGTGCCCAGAAATTCTGCGCCCTGATTATTCAGTATCAGGGTATTATGGAAACCGTTCGCATTCTGCTGTATGAAACCTGTCCGCGTTATCTGCTGGGTGTGCTGAATGCAGGTAAAGCAGATCTGCAGCGTCAGGTTAAACCGGAAGCATGGCTGAGTAGCGGCCCGAGTCCGGGTCCGGGTCGTCTTCAGCTGGTGTGTCATGTGAGTGGCTTCTATCCGAAACCGGTGTGGGTTATGTGGATGCGTGGTGAACAGGAACAGCAGGGCACCCAGCTGGGCGATATTCTGCCGAATGCCAATTGGACCTGGTATCTGCGCGCCACCCTGGATGTGGCCGATGGCGAAGCAGCCGGTCTGAGCTGTCGCGTTAAACATAGCAGCCTGGAAGGCCAGGATATTATTCTGTATTGGCGCAATCCGACCAGTATTGGTAGC\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: The CD1 multigene family encodes five forms of the CD1 T cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with β-2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q 23.1.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~32kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887057998003,"sku":"NCP0186-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887058030771,"sku":"NCP0186-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_62c3c760-b90c-4d72-8c0d-b4d3fb6e3879.jpg?v=1702317187","url":"https:\/\/afsbio.com\/products\/cd1b-recombinant-protein-ncp0186","provider":"AFSBio Inc.","version":"1.0","type":"link"}