{"product_id":"cd204-polyclonal-antibody-bt-ap14802","title":"CD204 Polyclonal Antibody - BT-AP14802","description":"\u003cp\u003eCD204 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP14802-20, BT-AP14802-50, BT-AP14802-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimerandapos;s disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; Immunology; Metabolism\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: MSR1\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: Macrophage scavenger receptor types I and II\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: P21757; Mouse: P30204\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: Macrophage scavenger receptor types I and II;Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204; Macrophage scavenger receptor types I and II; Macrophage acetylated LDL receptor I and II; Scavenger receptor class A member 1; CD antigen CD204\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 4481; Mouse: 20288\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45239083729075,"sku":"BT-AP14802-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45239083761843,"sku":"BT-AP14802-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45239083794611,"sku":"BT-AP14802-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f05095e1-17fe-4394-985e-1171ce2a7cc3.png?v=1769388883","url":"https:\/\/afsbio.com\/products\/cd204-polyclonal-antibody-bt-ap14802","provider":"AFSBio Inc.","version":"1.0","type":"link"}